Sodium Carbonate → HCID 131716669, compound

HRID 1587777Notes

Reaction equation

HRID 1587777 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][C:9]([CH3:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[N:7]2[N:19]=[CH:20][C:21]([C:22]#[N:23])=[C:6]12)=[O:4].C(=O)([O-])[O-].[Na+].[Na+].[CH2:30]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:55].Cl>C1(C)C=CC=CC=1>[ClH:1].[ClH:55].[Cl:18][C:14]1[CH:13]=[C:12]([C:8]2[N:7]3[N:19]=[CH:20][C:21]([C:22]#[N:23])=[C:6]3[N:5]([C:3](=[O:4])[CH2:2][N:40]3[CH2:41][CH2:42][N:37]([CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:38][CH2:39]3)[CH2:10][C:9]=2[CH3:11])[CH:17]=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 10340Sodium CarbonateHCID 759941-BenzylpiperazineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 15101087HCID 15101087, compound

Product 1

HCID 131716669HCID 131716669, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3.1 g of 4-(chloroacetyl)-7-(3-chlorophenyl)-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 1.1 g of sodium carbonate, 1.7 g of N-benzylpiperazine and 115 ml of toluene was reacted as described in Example 16, giving the base form of the product which was converted to the dihydrochloride salt by the procedure of Example 97, giving 1.3 g, mp 201°-203° C.

Workup

  1. customwas reacted
  2. customgiving the base form of the product which
  3. customgiving 1.3 g, mp 201°-203° C.

Sources & evidence

ORD record
ord-9b17a2570939473aa2e221f3477312c2
Source dataset
uspto-grants-1993_06
Patent number
US05219857

Reaction notes

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