HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[[4-[(2,6-Dichlorophenyl)methyl]-1-piperazinyl]acetyl]-4.5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2,6-Dichlorobenzyl)piperazine | HCID 770796 | — |
| Reactant | 4-(Chloroacetyl)-4,5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]-pyrimidine-3-carbonitrile | HCID 15101085 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-[[4-[(2,6-Dichlorophenyl)methyl]-1-piperazinyl]acetyl]-4.5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, hydrochloride | HCID 131716671 | — |
Reaction Steps
A mixture of 1 g of 4-(chloroacetyl)-7-[3-(trifluoromethyl)phenyl]-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 1 g of 2,6-dichlorobenzylpiperazine, 600 mg of potassium carbonate and 100 ml of toluene was reacted as described in Example 16, giving the base form of the product, which was converted to the hydrochloride salt by the procedure of Example 97, giving 1.66 g, mp 252°-254° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05219857 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-c68a3305bfbc4583bf6aea6c997dc202 |
| Source note | uspto-grants-1993_06 |