Sodium Carbonate → HCID 20077584, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product of step (i) (420 mg, 2 mmol) in THF (15 ml) was added to a suspension of lithium aluminium hydride (380 mg, 10 mmol) in THF (15 ml) with stirring at 0° C. under argon. After 1 hour a saturated aqueous solution of sodium carbonate (1 ml) was added dropwise and the mixture was stirred for a further 15 minutes before being filtered through a pad of diatomaceous earth, washing well with ethyl acetate. The filtrate was evaporated to give 1-hexyl-5-hydroxymethylimidazole (349 mg, 96% yield) as a solid; NMR: 0.8-0.95(3H,m), 1.2-1.45(6H,m), 1.7-1.9(2H,m), 3.99(2H,t,J=7.5 Hz), 4.62(2H,s), 6.93(1H,s), 7.46(1H,s).

Provenance & Evidence