Propanal → HCID 19088722, compound

HRID 1587815Notes

Reaction equation

HRID 1587815 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]([OH:21])([CH2:19][CH3:20])[CH2:17][OH:18])[CH:12]=[C:13]([F:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:22](=O)[CH2:23][CH3:24]>S(=O)(=O)(O)O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2([CH2:19][CH3:20])[CH2:17][O:18][CH:22]([CH2:23][CH3:24])[O:21]2)[CH:12]=[C:13]([F:15])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 527PropanalHCID 19088718HCID 19088718, compound

Product 1

HCID 19088722HCID 19088722, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

Using the procedure described in Example 1, 2-(3-benzyloxy-5-fluorophenyl)butane-1,2-diol (1.02 g) was reacted with propionaldehyde (6 ml) in the presence of concentrated sulphuric acid (1 drop) to give 4-(3-benzyloxy-5-fluorophenyl)-2,4-diethyl-1,3-dioxolane, as an oil and as a mixture of diastereoisomers. The product so obtained was hydrogenolysed using the procedure described in the portion of Example 6 which is concerned with the preparation of starting materials. There was thus obtained the required starting material (0.5 g, 60%), as an oil.

Sources & evidence

ORD record
ord-d5b48f7cc6ab4be9b57f62576f761eca
Source dataset
uspto-grants-1993_06
Patent number
US05219881

Reaction notes

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