HCID 19088483, compound → 2,2-Diphenyl-5-methylaminopentanamide

HRID 1587866Notes

Reaction equation

HRID 1587866 reaction equation
[CH2:1]([N:8]([CH2:10][CH2:11][CH2:12][C:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14]([NH2:16])=[O:15])C)C1C=CC=CC=1>C(O)C.[Pd]>[C:17]1([C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([CH2:12][CH2:11][CH2:10][NH:8][CH3:1])[C:14]([NH2:16])=[O:15])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 19088483HCID 19088483, compound

Product 1

HCID 190884752,2-Diphenyl-5-methylaminopentanamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 5-(N-benzyl-N-methylamino)-2,2-diphenylpentanamide (11 g-see Example 1) and 10% palladium-on-carbon (1.1 g) in ethanol (150 ml) was hydrogenated at room temperature and 50 p.s.i. (344.7 kPa) pressure for 87 hours. The mixture was filtered and the filtrate concentrated in vacuo to give an oil. The oil was triturated with ether to give the title compound as a colourless powder, yield 4.5 g.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated in vacuo
  4. customto give an oil
  5. customThe oil was triturated with ether

Sources & evidence

ORD record
ord-7839a95e41884c3c84c80423aa058dc9
Source dataset
uspto-grants-1993_06
Patent number
US05219871

Reaction notes

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