HCID 19088503, compound → HCID 19088472, compound

HRID 1587873Notes

Reaction equation

HRID 1587873 reaction equation
[CH2:1]([N:8]([C:10]([CH3:30])([CH3:29])[CH2:11][CH2:12][C:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14]([NH2:16])=[O:15])C)C1C=CC=CC=1>CO.C(O)=O.[Pd]>[C:17]1([C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([CH2:12][CH2:11][C:10]([CH3:30])([NH:8][CH3:1])[CH3:29])[C:14]([NH2:16])=[O:15])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 1

HCID 19088503HCID 19088503, compound

Product 1

HCID 19088472HCID 19088472, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 284Formic AcidSolventHCID 887MethanolSolvent

Procedure

10% Palladium-on-carbon was added to a solution of 5-(N-benzyl-N-methylamino)-2,2-diphenyl-5-methylhexanamide (0.6 g-see Example 3) in methanol (19 ml) and formic acid (1 ml). The mixture was stirred at room temperature for 16 hours then filtered and the filtrate concentrated in vacuo to give the title compound as a gum, yield 0.4 g.

Workup

  1. filtrationthen filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-c288961426aa46e090f030244b0183d2
Source dataset
uspto-grants-1993_06
Patent number
US05219871

Reaction notes

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