Acetonitrile → HCID 19088504, compound

Participants

Reaction Steps

A mixture containing 3-bromo-1,1-diphenylpropane (1.5 g-see Preparation 4), N-methyl-4-fluorophenethylamine (0.766 g-see CA 80:PIZ0985y), anhydrous potassium carbonate (1.38 g) and acetonitrile (50 ml) was heated under reflux for 24 hours then concentrated in vacuo. The residue was dissolved in water (40 ml) and extracted with dichloromethane (3×50 ml). The combined dichloromethane extracts were dried (Na2SO4) and concentrated in vacuo to give a gum which was purified by column chromatography on silica eluting with hexane containing dichloromethane (25% up to 100%) and then with dichloromethane containing methanol (0% up to 3%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a gum, yield, 0.51 g.

Provenance & Evidence