Sodium Hydroxide → HCID 14076219, compound

HRID 1587903Notes

Reaction equation

HRID 1587903 reaction equation
[C:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:27])[C:17]2[S:21][C:20]([NH:22][C:23](=[O:25])[CH3:24])=[N:19][C:18]=2[CH3:26])=[CH:8][CH:7]=1)([O:3]CC)=[O:2].[OH-].[Na+]>>[C:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:27])[C:17]2[S:21][C:20]([NH:22][C:23](=[O:25])[CH3:24])=[N:19][C:18]=2[CH3:26])=[CH:8][CH:7]=1)([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 14076218HCID 14076218, compound

Product 1

HCID 14076219HCID 14076219, compound

Procedure

Prepared analogously to Example 2 by reaction of N-[2-(4-carboethoxyphenyl)ethyl]-2-hydroxy-2-(2-acetylamino-4-methyl-thiazol-5-yl)ethanamine with 1N sodium hydroxide solution. After neutralisation with 1N hydrochloric acid, the mixture is evaporated to dryness, and the residue is recrystallised from 10 ml of water.

Workup

  1. customAfter neutralisation with 1N hydrochloric acid, the mixture is evaporated to dryness
  2. customthe residue is recrystallised from 10 ml of water

Sources & evidence

ORD record
ord-0ab5ff77497946208d059ab5d2d549aa
Source dataset
uspto-grants-1993_06
Patent number
US05219852

Reaction notes

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