HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- → N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- | HCID 14076239 | — |
| Reactant | 1-[4-(2-Carbomethoxy-1-methylethenyl)phenyl]propan-2-one | HCID 54548003 | — |
| Product | N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine | HCID 53895654 | — |
Reaction Steps
Prepared analogously to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-[4-(2-carbomethoxy-1-methylethenyl)phenyl]-propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/methanolic ammonia=9.5/0.4/0.1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05219852 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-d2984971d1ce4762a3248b2f88e89933 |
| Source note | uspto-grants-1993_06 |