Potassium Hydroxide → HCID 88464924, compound

HRID 1588054Notes

Reaction equation

HRID 1588054 reaction equation
[C:1]1([C:7]2[CH2:11][C:10]([P:16](=[O:19])([OH:18])[OH:17])([P:12](=[O:15])([OH:14])[OH:13])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+:21]>C(O)C>[K+:21].[C:1]1([C:7]2[CH2:11][C:10]([P:16](=[O:17])([OH:19])[O-:18])([P:12](=[O:13])([OH:14])[OH:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19756902HCID 19756902, compound

Product 1

HCID 88464924HCID 88464924, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

The free acid, [3-phenyl-5(4H)-isoxazolylidene]bisphosphonic acid, is then dissolved in ethanol (15 ml), treated with a solution of potassium hydroxide (560 mg, 10 mmol) in ethanol (10 ml), the precipitate collected and washed with ether to give the title compound, mp dec>250°; MS (m/e) 422, 384, 346 and 308; IR (mineral oil mull) 3054, 3029, 2317, 1609, 1572, 1497, 1206 and 1068 cm-1 ; NMR (D2O) 3.94 δ.

Workup

  1. customthe precipitate collected
  2. washwashed with ether

Sources & evidence

ORD record
ord-df3d64bf6b38430288ba5ac790b30126
Source dataset
uspto-grants-1993_06
Patent number
US05220021

Reaction notes

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