4-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)benzoic acid → 3-(4-Carboxyphenyl)-5-(4-beta-D-galactopyranosyloxy-3-methoxyphenylmethylene)-2-thioxothiazolidin-4-one

関与物質

反応手順

To a stirred suspension of 4-formyl-2-=methoxyphenyl β-D-galactopyranoside (1c)(0.47 g, 1.5 mmol) in absolute ethanol (25 ml) containing piperidine (1 drop), was added the potassium salt of 3-(4-carboxyphenyl)-2-thioxothiazolidin-4-one (0.44 g, 1.5 mmol) and the suspension was heated under gentle reflux for 2 h. A yellow solid separated which was filtered hot and washed with small portions of boiling methanol and ethyl acetate followed by ether to give the product (0.2 g, 22%) as the potassium salt, m.p. decomp.>230° C.

情報源と証拠