2'-Hydroxyacetophenone → HCID 19755424, compound

Participants

Reaction Conditions

Reaction Steps

20.2 g (0.2 mol) of formylaminoacetone [A. Treibs u.a., Chem. Ber. 84 96 (1951)] and 27.2 g (0.2 mol) of o-hydroxyacetophenone are dissolved in 100 ml of toluene, and 10 ml of pyrrolidine are added. The mixture is stirred at 25° C. for 20 hours and then at 115° C. for 2 hours. After cooling, the mixture is extracted by shaking successively with 2N HCl, 2N NaOH and water, the organic phase is concentrated and the 2-methyl-2-formylaminomethylchroman-4-one formed is isolated by chromatography. Melting point: 96°-8° C.

Provenance & Evidence