HCID 14651285, compound → HCID 15288444, compound

HRID 1588323Notes

Reaction equation

HRID 1588323 reaction equation
[F:1][C:2]1[C:3]([CH3:25])=[C:4]2[C:9](=[CH:10][C:11]=1F)[N:8]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[F:20])[CH:7]=[C:6]([C:21]([OH:23])=[O:22])[C:5]2=[O:24].[NH:26]1[CH2:30][CH2:29][CH:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[CH2:37][NH2:38])[CH2:27]1>>[NH2:38][CH2:37][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[CH:28]1[CH2:29][CH2:30][N:26]([C:11]2[CH:10]=[C:9]3[C:4]([C:5](=[O:24])[C:6]([C:21]([OH:23])=[O:22])=[CH:7][N:8]3[C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=3[F:20])=[C:3]([CH3:25])[C:2]=2[F:1])[CH2:27]1

Participants

3

Reactant 2

HCID 14651285HCID 14651285, compoundHCID 152884282-(3-Pyrrolidinyl)benzenemethanamine

Product 1

HCID 15288444HCID 15288444, compoundYield 72%

Procedure

Starting from 6,7-difluoro-1-(2,4 difluorophenyl)-1,4 dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid (0.40 g, 1.1 mmol) and 2-(3 pyrrolidinyl)benzenemethanamine, a procedure analogous to that given in Example 1, provided the title compound (0.40 g, 72%) as a beige solid, mp 283°-285° C. (dec).

Sources & evidence

ORD record
ord-4d84264b9cdb48e38dd372acd0cca9b3
Source dataset
uspto-grants-1993_06
Patent number
US05221676

Reaction notes

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