Acetyl chloride → HCID 19896706, compound

HRID 1588333Notes

Reaction equation

HRID 1588333 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([OH:17])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[C:20](Cl)(=O)C>CO>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([O:17][CH3:20])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 11065271HCID 11065271, compound

Product 1

HCID 19896706HCID 19896706, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-Oxo-3-methylbutyric acid (5 g) was suspended in methanol (50 ml) and acetyl chloride (0.5 ml) added. The mixture was heated on a steam bath until all of the solid dissolved. The solvent was evaporated at reduced pressure providing the ester as a white foam which was recrystallized from ethyl acetate-methanol to give the product as white crystals, yield 5 g, mp 95°-98° C.

Workup

  1. temperatureThe mixture was heated on a steam bath until all of the solid
  2. dissolutiondissolved
  3. customThe solvent was evaporated at reduced pressure

Sources & evidence

ORD record
ord-0d9dfcf3a5f0431eba040eb878f71927
Source dataset
uspto-grants-1993_06
Patent number
US05221742

Reaction notes

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