Methylhydrazine → HCID 9903609, compound

HRID 1588337Notes

Reaction equation

HRID 1588337 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=O)[CH:13]([CH3:18])[CH2:14][C:15](O)=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[CH3:20][NH:21][NH2:22]>C(O)C>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]3[CH:13]([CH3:18])[CH2:14][C:15](=[O:16])[N:21]([CH3:20])[N:22]=3)=[CH:11][C:5]=2[O:4][CH2:3]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 11065271HCID 11065271, compound

Product 1

HCID 9903609HCID 9903609, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-oxo-3-methylbutyric acid (1.56 g, 6.0 mmoles) was dissolved in ethanol (300 ml) and methylhydrazine (0.33 ml, 6.0 mmoles) was added. The mixture was heated at reflux for 2 hours, and then cooled to yield to yield the titled compound. The crystals were collected by filtration, recrystallized from ethanol, and recollected by filtration. The solid was dried under vacuum to yield 1.0 g of the titled compound, mp 204°-206° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 2 hours
  3. temperaturecooled
  4. customto yield

Sources & evidence

ORD record
ord-ab293ee570ac4156938e385ba76c9c40
Source dataset
uspto-grants-1993_06
Patent number
US05221742

Reaction notes

Loading…