反应详情

5.0 g of 4-fluoronitrobenzene, 5.0 g of 5-t-butyl-3-hydroxyisoxazole, 4.0 g of potassium t-butoxide, and 70 ml of toluene were mixed, and after adding 0.5 g of 1-(2-ethylhexyl)pyridinium chloride to the mixture, the resultant mixture was refluxed for 10 hours. The reaction mixture obtained was cooled and carefully applied to silica gel column chromatography to provide 0.6 g of the above-described compound with a yield of 6.5%. The melting point thereof was 125° C. to 127° C.

1. customThe reaction mixture obtained
2. temperaturewas cooled