p-Fluoronitrobenzene → 5-t-Butyl 2-(4-nitrophenyl)-4-isoxazolin-3-one

HRID 1588386노트

반응식

HRID 1588386 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[C:11]([C:15]1[O:19][N:18]=[C:17]([OH:20])[CH:16]=1)([CH3:14])([CH3:13])[CH3:12].CC(C)([O-])C.[K+].[Cl-].C(C(CCCC)C[N+]1C=CC=CC=1)C>C1(C)C=CC=CC=1>[C:11]([C:15]1[O:19][N:18]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[C:17](=[O:20])[CH:16]=1)([CH3:14])([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 9590p-FluoronitrobenzeneHCID 226089861-(2-Ethylhexyl)pyridinium chlorideHCID 23665647Potassium tert-butoxideHCID 178441207HCID 178441207, 화합물

생성물 1

HCID 143245185-t-Butyl 2-(4-nitrophenyl)-4-isoxazolin-3-one수율 6.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

5.0 g of 4-fluoronitrobenzene, 5.0 g of 5-t-butyl-3-hydroxyisoxazole, 4.0 g of potassium t-butoxide, and 70 ml of toluene were mixed, and after adding 0.5 g of 1-(2-ethylhexyl)pyridinium chloride to the mixture, the resultant mixture was refluxed for 10 hours. The reaction mixture obtained was cooled and carefully applied to silica gel column chromatography to provide 0.6 g of the above-described compound with a yield of 6.5%. The melting point thereof was 125° C. to 127° C.

후처리

  1. customThe reaction mixture obtained
  2. temperaturewas cooled

출처 및 근거

ORD 기록
ord-d56b44bf35f344ecbf1f6d32a799c133
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05221750

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