1,4-Dioxane hydrochloride → HCID 131717998, compound

HRID 1588397Notes

Reaction equation

HRID 1588397 reaction equation
[CH2:1]([O:8][C:9](=[O:39])[C@H:10]([CH:36]([CH3:38])[CH3:37])[NH:11][C:12](=[O:35])[C@@H:13]([CH2:31][CH:32]([CH3:34])[CH3:33])[NH:14]C(=O)C(O)C1CCCN1C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:40].O1CCOCC1>ClCCl>[ClH:40].[CH2:1]([O:8][C:9](=[O:39])[C@H:10]([CH:36]([CH3:38])[CH3:37])[NH:11][C:12](=[O:35])[C@H:13]([CH2:31][CH:32]([CH3:33])[CH3:34])[NH2:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53725089HCID 53725089, compound

Product 1

HCID 131717998HCID 131717998, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[2-Hydroxy-2-(N-t-butyloxycarbonylpyrrolidin-2-yl)acetyl]-D-leucylvaline benzyl ester (200 mg) was added to dry dichloromethane (1 ml) and 4N hydrochloric acid/dioxane (1 ml) was added to the solution under cooling with ice to conduct a reaction at room temperature for 1.5 h. The reaction liquid was concentrated under reduced pressure and the residue was washed with n-hexane and dried to give 2-hydroxy-2-(pyrrolidin-2-yl)acetyl]-D-leucylvaline benzyl ester hydrochloride.

Workup

  1. additionwas added to the solution
  2. temperatureunder cooling with ice
  3. customa reaction at room temperature for 1.5 h
  4. customThe reaction liquid
  5. concentrationwas concentrated under reduced pressure
  6. washthe residue was washed with n-hexane
  7. customdried

Sources & evidence

ORD record
ord-72d44d292c22496e96da998e7f01f4a3
Source dataset
uspto-grants-1993_06
Patent number
US05221752

Reaction notes

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