1,4-Dioxane hydrochloride → HCID 70073552, compound

HRID 1588398Notes

Reaction equation

HRID 1588398 reaction equation
[CH2:1]([O:8][C:9](=[O:39])[C@H:10]([CH:36]([CH3:38])[CH3:37])[NH:11][C:12](=[O:35])[C@@H:13]([CH2:31][CH:32]([CH3:34])[CH3:33])[NH:14][C:15](=[O:30])[CH:16]([OH:29])[CH:17]1[CH2:21][CH2:20][CH2:19][N:18]1C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:40].O1CCOCC1>ClCCl>[ClH:40].[CH2:1]([O:8][C:9](=[O:39])[C@H:10]([CH:36]([CH3:38])[CH3:37])[NH:11][C:12](=[O:35])[C@@H:13]([CH2:31][CH:32]([CH3:33])[CH3:34])[NH:14][C:15](=[O:30])[CH:16]([OH:29])[CH:17]1[CH2:21][CH2:20][CH2:19][NH:18]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53725089HCID 53725089, compound

Product 1

HCID 70073552HCID 70073552, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[2-Hydroxy-2-(N-t-butyloxycarbonylpyrrolidin-2-yl)acetyl]-D-leucylvaline benzyl ester (100 mg) was dissolved in dichloromethane (1 ml) and 1 ml of a 4N hydrochloric acid/dioxane solution was added to the solution under cooling with ice to conduct a reaction at room temperature for 2 h. The reaction liquid was concentrated under reduced pressure and the residue was washed with n-hexane several times and concentrated to give [2-hydroxy-2-(pyrrolidin-2-yl)acetyl]-D-leucylvaline benzyl ester hydrochloride.

Workup

  1. temperatureunder cooling with ice
  2. customa reaction at room temperature for 2 h
  3. customThe reaction liquid
  4. concentrationwas concentrated under reduced pressure
  5. washthe residue was washed with n-hexane several times
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-48cc8a6a1b4c4bebb94ae60acb784197
Source dataset
uspto-grants-1993_06
Patent number
US05221752

Reaction notes

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