1,4-Dioxane hydrochloride → HCID 70074454, compound

HRID 1588399Notes

Reaction equation

HRID 1588399 reaction equation
[CH2:1]([O:8][C:9](=[O:40])[C@H:10]([CH:37]([CH3:39])[CH3:38])[NH:11][C:12](=[O:36])[C@@H:13]([CH2:32][CH:33]([CH3:35])[CH3:34])[NH:14][C:15](=[O:31])[CH:16]([OH:30])[CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][N:18]1C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:41].O1CCOCC1>ClCCl>[ClH:41].[CH2:1]([O:8][C:9](=[O:40])[C@H:10]([CH:37]([CH3:39])[CH3:38])[NH:11][C:12](=[O:36])[C@@H:13]([CH2:32][CH:33]([CH3:34])[CH3:35])[NH:14][C:15](=[O:31])[CH:16]([OH:30])[CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][NH:18]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53772882HCID 53772882, compound

Product 1

HCID 70074454HCID 70074454, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[2-Hydroxy-2-(N-t-butyloxycarbonylpiperidin-2-yl)acetyl]-D-leucylvaline benzyl ester (85 mg) was dissolved in dichloromethane (1 ml) and a 4N hydrochloric acid/dioxane solution (1 ml) was added to the solution under cooling with ice to conduct a reaction at room temperature for 2 h. The reaction liquid was concentrated under reduced pressure and the residue was washed with n-hexane several times and dried to give [2-hydroxy-2-(piperidin-2-yl)acetyl]-D-leucylvaline benzyl ester hydrochloride.

Workup

  1. temperatureunder cooling with ice
  2. customa reaction at room temperature for 2 h
  3. customThe reaction liquid
  4. concentrationwas concentrated under reduced pressure
  5. washthe residue was washed with n-hexane several times
  6. customdried

Sources & evidence

ORD record
ord-6c8af84295c2481fb239de8df384d5ec
Source dataset
uspto-grants-1993_06
Patent number
US05221752

Reaction notes

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