反应详情

A mixture containing 2-(chloromethyl)quinoline hydrochloride (100.0 g), 4-acetamidophenol (70.69 g) and milled anhydrous K2CO3 (194 g) was stirred in DMF (1.2 L) using a mechanical stirrer for 48 hours. The mixture was carefully poured onto ice/water (3 L) with vigorous stirring. After the ice had melted, the solid was filtered and rinsed thoroughly with H2O. It was recrystallized from 95% EtOH (ethanol) and filtered to give N-acetyl-4-(quinolin-2-ylmethoxy)aniline in three crops.

1. customfor 48 hours
2. additionThe mixture was carefully poured onto ice/water (3 L) with vigorous stirring
3. filtrationthe solid was filtered
4. washrinsed thoroughly with H2O
5. customIt was recrystallized from 95% EtOH (ethanol)
6. filtrationfiltered