Diazomethane → HCID 54213326, compound

HRID 1588436Notes

Reaction equation

HRID 1588436 reaction equation
[C:1]1([C:7]2[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([OH:16])=[O:15])[C:9](=[O:17])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+](=[CH2:20])=[N-]>CCOCC>[C:1]1([C:7]2[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([O:16][CH3:20])=[O:15])[C:9](=[O:17])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 14418385HCID 14418385, compound

Product 1

HCID 54213326HCID 54213326, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 4-phenyl-2-oxo-3-cyclohexene-1-acetic acid (Tet. Lett. 1968, 4739) (10.0 g, 43.4 mmol) in Et2O (150 ml) was treated with ethereal diazomethane at 0° C. until TLC indicated the reaction to be complete. The solvent was evaporated to yield methyl 4-phenyl-2-oxo-3-cyclohexene-1-acetate (10.6 g, quant.): Rf 0.33 (20% EtOAc in hexane);

Workup

  1. customthe reaction
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-cba6aac9c46343b4af63519234b64cf7
Source dataset
uspto-grants-1993_06
Patent number
US05221678

Reaction notes

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