Hydrochloric Acid → HCID 86746994, compound

Participants

Reaction Steps

To the above solution was added a solution of methyl (Z)-7-[(1R)-(2R,3R,5S)-2-{5,5-difluoro-4(RS)-hydroxyoctyl}-5-hydroxy-3-tetra-hydropyranyloxycyclopentyl]hept-5-enoate (18) (0.244 g) in methylene chloride. The resultant mixture was warmed to -25° C. and stirred for 1 hour. Triethylamine (0.60 ml) was added thereto and the reaction mixture was stirred for additional 30 minutes, poured into 1N hydrochloric acid, and then worked up with the conventional procedure. The obtained product was subjected to silicagel column chromatography to give the titled compound (19).

Provenance & Evidence