1,4-Dioxane → HCID 178508856, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 0.4 g (1.2 mM) of 2,4-diamino-6-[2-(3,5-dichlorophenyl)ethenyl]pyrido[2,3-d]pyrimidine (prepared as described in Example 3), in 80 ml of 1N sodium hydroxide was heated at reflux for 24 hours. Since not all the starting material had dissolved, 10 ml of 5N sodium hydroxide and 25 ml of dioxane were added, and the mixture was heated at reflux for an additional 24 hours. The reaction mixture was cooled to 24° C., filtered, and the filtrate was diluted with 30 ml of glacial acetic acid. The precipitate which formed was collected by filtration, washed with 50 ml of water, and then with 50 ml of diethyl ether, and dried at 100° C. under vacuum to provide 160 mg of 2-amino-4-hydroxy-6-[2-(3,5-dichlorophenyl)ethenyl]pyrido-[2,3-d]pyrimidine.

Provenance & Evidence