4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamide

HRID 1588509ノート

反応式

HRID 1588509 の反応式
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([CH3:13])=[CH:15][CH:16]=1)#[N:2]

参加物

4

反応物 2

HCID 660354-MethylbenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

生成物 1

HCID 19734553N-cyano-N'-(4-methylbenzyl)-2-pyridinecarboximidamide収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl N-cyano-2-pyridinecarboximidate (0.30 g, 1.9 mmol) was dissolved in methanol (10 ml), p-methylbenzylamine (0.25 g, 2.1 mmol) was added, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.41 g, 1.6 mmol, yield: 91%) as colorless crystals.

後処理

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

出典と根拠

ORDレコード
ord-3c78812d25bd4d5faee51f962b542967
出典データセット
uspto-grants-1993_06
特許番号
US05223508

反応ノート

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