4-Chlorobenzylamine → N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide

HRID 1588510ノート

反応式

HRID 1588510 の反応式
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH2:18][C:17]1[CH:20]=[CH:21][C:14]([Cl:13])=[CH:15][CH:16]=1)#[N:2]

参加物

4

反応物 2

HCID 660364-ChlorobenzylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

生成物 1

HCID 19734551N-cyano-N'-(4-chlorobenzyl)-2-pyridinecarboximidamide収率 16.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 4-chlorobenzylamine (0.48 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 5 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.13 g, 0.5 mmol, yield: 16%) as colorless crystals.

後処理

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

出典と根拠

ORDレコード
ord-57e5f644fdb142658117c2f4aea6f877
出典データセット
uspto-grants-1993_06
特許番号
US05223508

反応ノート

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