反应详情

To a stirred solution of 2-amino-4-methyl-3-nitropyridine (25.6 g, 167 mmol) in conc. H2SO4 (50 mL) at 0° C. was added HNO3 (7.77 mL, d=1.49) drop-wise over 30 min. The mixture was warmed to r.t. for 1 h then heated to 50° C. for 60 min. The reaction mixture was cooled and poured into 500 g of ice. The resulting precipitate was filtered, washed with 50 mL of H2O, and air dried to give 2-amino-4-methyl-3,5-dinitro-pyridine as a yellow solid.

1. temperaturethen heated to 50° C. for 60 min
2. temperatureThe reaction mixture was cooled
3. filtrationThe resulting precipitate was filtered
4. washwashed with 50 mL of H2O, and air
5. customdried