Isobutyronitrile → HCID 178503245, compound

HRID 1588595Notes

Reaction equation

[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:7]([CH:9]=1)[NH2:8].[C:16](#[N:20])[CH:17]([CH3:19])[CH3:18].[Cl-].[Al+3].[Cl-].[Cl-]>>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:7]([NH:8][C:16](=[NH:20])[CH:17]([CH3:19])[CH3:18])[CH:9]=1

Participants

Reactant 3

HCID 6559Isobutyronitrile

HCID 6451240Aluminum(III) Chloride

HCID 18952214HCID 18952214, compound

Product 1

HCID 178503245HCID 178503245, compound

Conditions

Temperature: 140 °C

Procedure

A mixture of 5-methylthio-2-morpholinoaniline (1.8 g), isobutyronitrile (1.66 g) and anhydrous aluminium chloride (3.2 g) was heated at 140° C. for 2 hours to give N-(5-methylthio-2-morpholinophenyl) isobutyramidine (m.p. 155° C.) which was recrystallised from hexane.

Sources & evidence

ORD record: ord-be69bce8f4ba4ce2842c317b43915938
Source dataset: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05223498

Reaction notes

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