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2-Piperidone → 4-[2-(2-Piperidinylideneamino)benzyl]morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Piperidone | HCID 12665 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 2-(Morpholin-4-ylmethyl)aniline | HCID 6484555 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 4-[2-(2-Piperidinylideneamino)benzyl]morpholine | HCID 178420475 | — |
反応手順
A mixture of 2-piperidone (3.6 g) in benzene (30 ml), 4-(2-aminobenzyl)morpholine (5.7 g) in benzene (20 ml) and phosphorus oxychloride (3.6 ml) was heated at 65°-70° C. for 48 hours to yield 4-[2-(2-piperidinylideneamino)benzyl]morpholine (m.p. 108°-110° C.) which was recrystallised from hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05223498 |
| 出典データセット | uspto-grants-1993_06 |
| ORD ID | ord-c43ada19304b4d36a5f0291be5881661 |
| 出典メモ | uspto-grants-1993_06 |