Methyl isothiocyanate → HCID 15746499, compound

HRID 1588660Notes

Reaction equation

HRID 1588660 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:13][N:14]=[C:15]=[S:16]>ClCCl>[CH3:13][NH:14][C:15]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[S:16]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 9375012-pyrrolidin-1-ylaniline

Product 1

HCID 15746499HCID 15746499, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Reaction of 1-(2-aminophenyl)pyrrolidine (10 g) with methyl isothiocyanate (6.3 g) in dichloromethane (45 ml) at room temperature for 4 days gave 1-methyl-3-[2-(1-pyrrolidinyl)phenyl]thiourea (m.p. 125°-126° C.).

Sources & evidence

ORD record
ord-4f96dfa3474545759d5816c65a016a6c
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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