Ammonia → HCID 18952324, compound

HRID 1588674Notes

Reaction equation

HRID 1588674 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=2[N:17]=[C:18]=[S:19])[CH2:3][CH2:2]1.[NH3:20]>C(O)C>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=2[NH:17][C:18]([NH2:20])=[S:19])[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18952335HCID 18952335, compound

Product 1

HCID 18952324HCID 18952324, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 2-morpholino-5-trifluoromethylphenyl isothiocyanate (12 g) in ethanol (20 ml) with 33% ethanolic ammonia solution (50 ml) at room temperature for 2 hours gave 1-(2-morpholino-5-trifluoromethylphenyl)thiourea (m.p. 196°-197° C.).

Sources & evidence

ORD record
ord-f99ffd33a1554c63b4a0f4031283a7c8
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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