Potassium Hydroxide → N-(5-chloro-2-morpholinophenyl)cyanamide

HRID 1588687Notes

Reaction equation

HRID 1588687 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([NH:8][C:9]([NH2:11])=S)[CH:7]=1.O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C.[OH-].[K+]>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([NH:8][C:9]#[N:11])[CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 189522431-(5-Chloro-2-morpholinophenyl)thiourea

Product 1

HCID 18952323N-(5-chloro-2-morpholinophenyl)cyanamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A mixture of 1-(5-chloro-2-morpholinophenyl) thiourea (5.97 g) suspended in water (40 ml), lead acetate trihydrate (8.75 g) in water (40 ml) and potassium hydroxide (12.6 g) in water (35 ml) was heated under reflux for 15 minutes to give N-(5-chloro-2-morpholinophenyl)cyanamide as a white solid (m.p. 305°-308° C.).

Workup

  1. temperatureunder reflux for 15 minutes

Sources & evidence

ORD record
ord-8d37ee94fe97416fb78e95e4d76b1041
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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