Dimethylamine → HCID 18952223, compound

Participants

Reaction Steps

In a similar manner to that described in Example 286, N-(3-methyl-2-morpholinophenyl)cyanamide (2.5 g) in ethanol (8 ml) and a 33% ethanolic solution of dimethylamine (3.5 ml) were heated under reflux for 1 hour. A further amount of the 33% ethanolic solution of dimethylamine (3.5 ml) was added and the mixture heated under reflux for a further hour to give 1,1-dimethyl-2-(3-methyl-2-morpholinophenyl)guanidine (m.p. 100° C.) which was recrystallised from hexane and converted into its monofumarate salt (m.p. 180° C.) which was recrystallised from a 1:1 mixture of methanol and ether.

Provenance & Evidence