反应详情

A mixture of N-(2-morpholinophenyl)cyanamide (1.5 g) and a 33% ethanolic solution of dimethylamine (12 ml) was heated under reflux for 4 hours. Removal of solvent gave a residue to which was added dichloromethane (100 ml) and brine (50 ml). The mixture was stirred for 5 minutes and the organic layer separated and dried. Removal of the solvent gave 1,1-dimethyl-2-(2-morpholinophenyl)guanidine (m.p. 144°-145° C.) which was recrystallised from hexane.

1. temperatureunder reflux for 4 hours
2. customRemoval of solvent
3. customgave a residue to which
4. customthe organic layer separated
5. customdried
6. customRemoval of the solvent