反应详情

A mixture of N-methyl-N'-(2-morpholinophenyl)carbodiimide (1 g), n-butylamine (0.5 g) and t-butanol (5 ml) was heated at 90°-95° C. for four hours. The solvent was removed by evaporation and the residue dissolved in dichloromethane (100 ml) and the resulting solution was washed with water, dried and filtered. Removal of the solvent gave 1-(n-butyl)-2-(2-morpholinophenyl)- 3-methylguanidine which was converted into its monofumarate salt (m.p. 178°-179° C..).

1. temperaturewas heated at 90°-95° C. for four hours
2. customThe solvent was removed by evaporation
3. dissolutionthe residue dissolved in dichloromethane (100 ml)
4. washthe resulting solution was washed with water
5. customdried
6. filtrationfiltered
7. customRemoval of the solvent