Cyclopropylamine → HCID 178511861, compound

HRID 1588706Notes

Reaction equation

HRID 1588706 reaction equation
CS[C:3](=[NH:8])[NH:4][N+:5]([O-:7])=[O:6].[CH:9]1([NH2:12])[CH2:11][CH2:10]1>C(O)C>[CH:9]1([NH:12][C:3]([NH:4][N+:5]([O-:7])=[O:6])=[NH:8])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178511861HCID 178511861, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
-5 °C

Procedure

27 g of S-methyl-N-nitroisothiourea are heated under reflux for 3.5 hours in admixture with 12.6 g of cyclopropylamine and 15 ml of ethanol. The reaction mixture is then cooled to -5° C. and the product is filtered off and washed with a small amount of cold ethanol and diethyl ether, yielding N-cyclopropyl-N'-nitroguanidine (m.p.: 127°-130° C.).

Workup

  1. filtrationthe product is filtered off
  2. washwashed with a small amount of cold ethanol and diethyl ether

Sources & evidence

ORD record
ord-eb801d53c27e47af88b48279d71e5fc0
Source dataset
uspto-grants-1993_06
Patent number
US05223520

Reaction notes

Loading…