Dimethylformamide diethylacetal → HCID 137226493, compound

HRID 1588707Notes

Reaction equation

HRID 1588707 reaction equation
[CH:1]1([NH:4][C:5]([NH:7][N+:8]([O-:10])=[O:9])=[NH:6])[CH2:3][CH2:2]1.C(O[CH:14](OCC)[N:15]([CH3:17])[CH3:16])C>>[CH:1]1([NH:4][C:5]([N:6]=[CH:14][N:15]([CH3:17])[CH3:16])=[N:7][N+:8]([O-:10])=[O:9])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 178511861HCID 178511861, compound

Product 1

HCID 137226493HCID 137226493, compound

Procedure

14.4 g of N-cyclopropyl-N'-nitroguanidine are added to 14.7 g of N,N-dimethylformamide-diethyl-acetal. After stirring at 70°-75° C. for 1.5 hours, the mixture is cooled and concentrated using a rotary evaporator. The crude product is stirred into diethyl ether, filtered off and washed with further diethyl ether, yielding N-cyclopropyl-N'-(N,N-dimethylaminomethylene)-N"-nitroguanidine (m.p.: 120°-122° C.).

Workup

  1. temperaturethe mixture is cooled
  2. concentrationconcentrated
  3. customa rotary evaporator
  4. stirringThe crude product is stirred into diethyl ether
  5. filtrationfiltered off
  6. washwashed with further diethyl ether

Sources & evidence

ORD record
ord-a57f0bbf574d4271a2ef3a0a174d5957
Source dataset
uspto-grants-1993_06
Patent number
US05223520

Reaction notes

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