Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrabutylammonium Fluoride → alpha-Ethynylbenzenemethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 반응물 | 1-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol | HCID 2760416 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | alpha-Ethynylbenzenemethanol | HCID 20155 | — |
반응 단계
Place a mixture of α-[(trimethylsilyl)ethynyl]-benzene-methanol (1.87 g, 9.13mmol) and tetrahydrofuran (11 mL) under argon atmosphere. Add, by dropwise addition, tetra-n-butylammonium fluoride (11 mL of a 1M solution in tetrahydrofuran, 11 mmol). Stir for 1 hour at room temperature and partition between ethyl ether and water. Separate the organic phase, wash with saturated aqueous sodium chloride, dry (MgSO4), filter, and concentrate in vacuo to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05223518 |
| 출처 데이터셋 | uspto-grants-1993_06 |
| ORD ID | ord-3c830598d89149feb4735d7649e831d5 |
| 출처 메모 | uspto-grants-1993_06 |