참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-Amino-5-chlorobenzophenone | HCID 12870 | — |
| 생성물 | Ethyl 6-chloro-2-oxo-4-phenyl-1,2-dihydro-3-quinolinecarboxylate | HCID 738703 | 79.3% |
반응 단계
A mixture of 2-amino-5-chlorobenzophenone (6.93 g), diethyl malonate (7.2 g) and piperidine (0.3 ml) was heated at 170° C. for 4 hours. After cooling, isopropyl ether was added to the mixture to obtain crystals of ethyl 6-chloro-1,2-dihydro-2-oxo-4-phenyl-3-quinolinecarboxylate (7.77 g, 79.3%). The crystals was recrystallized from ethanol to give pale-yellowish needles. mp 223°-224° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05223513 |
|---|
| 출처 데이터셋 | uspto-grants-1993_06 |
|---|
| ORD ID | ord-f231e14c85cd4fceadc86fc7a104ecc2 |
|---|
| 출처 메모 | uspto-grants-1993_06 |
|---|
