Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → Ethyl 6-chloro-1,2-dihydro-1-methyl-2-oxo-4-phenyl-3-quinolinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-(Methylamino)-5-chlorobenzophenone | HCID 13925 | — |
| 생성물 | Ethyl 6-chloro-1,2-dihydro-1-methyl-2-oxo-4-phenyl-3-quinolinecarboxylate | HCID 10405076 | 73.1% |
반응 단계
A mixture of 5-chloro-2-methylaminobenzophenone (1.23 g), diethyl malonate (1.6 g) and piperidine (0.1 ml) was heated for 3 hours at 170°-180° C. After cooling, the mixture was treated with isopropyl ether to give crystals, which were recrystallized from ethanol to afford ethyl 6-chloro-1,2-dihydro-1-methyl-2-oxo-4-phenyl-3-quinolinecarboxylate (1.25 g, 73.1%). mp 124°-125° C. The product was identical with the compound obtained in Reference Example 12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05223513 |
| 출처 데이터셋 | uspto-grants-1993_06 |
| ORD ID | ord-54191ea06d1f4bf3b784a8d02b8317e6 |
| 출처 메모 | uspto-grants-1993_06 |