反应详情

Chlorosulfonic acid (5 ml) was cooled to 0° C. and the 5-benzyl-2,4-thiazolidinedione prepared above (9.6 mmol, 2.0 g) was added portionwise. The reaction mixture was stirred at room temperature for 0.5 hour and poured into ice (25 g). The solution was extracted with methylene chloride (2×50 ml) and the organic layers were dried (Na2SO4) and solvent removed in vacuo to afford title product which was used without further purification.

1. additionwas added portionwise
2. extractionThe solution was extracted with methylene chloride (2×50 ml)
3. dry with materialthe organic layers were dried (Na2SO4) and solvent
4. customremoved in vacuo