Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Methyl 2-(Dimethoxymethyl)pyridine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Trimethyl orthoformate | HCID 9005 | — |
| 반응물 | Methyl 6-formylpyridine-3-carboxylate | HCID 586269 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 2-(Dimethoxymethyl)pyridine-5-carboxylate | HCID 14459972 | 75% |
반응 단계
To a solution of methyl 2-formylpyridine-5-carboxylate (2.00 g, 12.1 mmol) in methanol (20 ml) and trimethyl orthoformate (5 ml) was added H2SO4 (conc., 1.5 ml). After refluxing overnight, the reaction was cooled and concentrated to a thick slurry and then poured into saturated NaHCO3 (50 ml). The latter was extracted with ether (3×30 ml) and the combined organic layers dried (MgSO4) and concentrated to afford title product (1.91 g, 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05223522 |
| 출처 데이터셋 | uspto-grants-1993_06 |
| ORD ID | ord-16c82fa9c943469ab2e75448a25e0d18 |
| 출처 메모 | uspto-grants-1993_06 |