反应详情

Ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (22.3 g) was added to a solution of sodium hydroxide (4.4 g) in methanol (200 mL). The contents were heated at reflux for 1 h, then cooled and stirred overnight. The contents were concentrated in vacuo and diluted with water. The aqueous solution was made acidic with 2N HCl and the precipitated white solid was filtered to give the desired acid (18.2 g).

1. temperatureThe contents were heated
2. temperatureat reflux for 1 h
3. temperaturecooled
4. concentrationThe contents were concentrated in vacuo
5. additiondiluted with water
6. filtrationthe precipitated white solid was filtered