Hydrogen Peroxide → HCID 19754553, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 800 mg (1.93 mmole) of 1-(2,6-dichloro-4-trifluoromethylphenyl)-2-chloro-4-trifluoromethylsulfenylimidazole in trifluoroacetic acid was added 0.20 ml of 30% hydrogen peroxide at 0° C. The resulting mixture was stirred at 0° C. for 4 h and then at RT for 50 h. The mixture was evaporated at RT and the residue was partitioned between methylene chloride and a saturated aqueous sodium bisulfite solution. The organic layer was washed with an aqueous sodium bicarbonate solution and the organic layer was evaporated. The residue was purified by flash column chromatography on silica gel using 5% ethyl acetate in hexane. After the solvent was removed there was obtained 300 mg (36.02% yield) of the desired product as a white solid, mp 147.5° C.

Provenance & Evidence