3-Methoxyphenyl isocyanate → HCID 14880503, compound

HRID 1588840Notes

Reaction equation

HRID 1588840 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([N:26]=[C:27]=[O:28])[CH:23]=[CH:24][CH:25]=1>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:26][C:27](=[O:28])[NH:1][CH2:2][C:3]([N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:4])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 878433-Methoxyphenyl isocyanateHCID 14880491HCID 14880491, compound

Product 1

HCID 14880503HCID 14880503, compoundYield 79.5%

Procedure

Working in a manner similar to that described in Example 1, but starting with 2-amino-N,N-diphenylacetamide (2 g) and 3-methoxyphenyl isocyanate (1.3 g), and after recrystallization in acetonitrile, 2-[3-(3-methoxyphenyl)ureido]-N,N-diphenylacetamide (2.6 g), m.p. 182° C., is obtained.

Workup

  1. customafter recrystallization in acetonitrile

Sources & evidence

ORD record
ord-a56ecb7603904b05aa4c946888c3c9ca
Source dataset
uspto-grants-1993_06
Patent number
US05223529

Reaction notes

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