Boron tribromide → HCID 14880504, compound

Participants

Reaction Conditions

Reaction Steps

A 1M methylene chloride solution (25 cc) of boron tribromide is added in the course of 15 minutes at a temperature in the region of -50° C. to a solution, maintained under a nitrogen atmosphere, of 2-[3-(3-methoxyphenyl)ureido]-N,N-diphenylacetamide (1.6 g) in dichloromethane (25 cc). The mixture obtained is stirred for 2 hours at a temperature in the region of -50° C. and then for 20 hours at a temperature in the region of 20° C. The precipitate formed is separated by filtration, washed with distilled water (6×10 cc) and dried in the air. After recrystallization in acetonitrile, 2-[3-(3-hydroxyphenyl)ureido]-N,N-diphenylacetamide (0.5 g), m.p. 244° C., is obtained.

Provenance & Evidence