m-Tolyl isocyanate → HCID 14880515, compound

HRID 1588844Notes

Reaction equation

HRID 1588844 reaction equation
[NH2:1][CH:2]([CH3:18])[C:3]([N:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:19][C:20]1[CH:21]=[C:22]([N:26]=[C:27]=[O:28])[CH:23]=[CH:24][CH:25]=1>>[CH3:19][C:20]1[CH:21]=[C:22]([NH:26][C:27](=[O:28])[NH:1][CH:2]([CH3:18])[C:3]([N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:4])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14880493HCID 14880493, compound

Product 1

HCID 14880515HCID 14880515, compoundYield 43.2%

Procedure

Working in a manner similar to that described in Example 1, but starting with (RS)-2-amino-N,N-diphenylpropionamide (1.2 g) and 3-methylphenyl isocyanate (0.66 g), and after recrystallization in methanol, (RS)-2-[3-(3-methylphenyl)ureido]-N,N-diphenylpropionamide (0.8 g), m.p. 197° C., is obtained.

Workup

  1. customafter recrystallization in methanol

Sources & evidence

ORD record
ord-77d06e4d11474ae4bd01e0ef02d85d2e
Source dataset
uspto-grants-1993_06
Patent number
US05223529

Reaction notes

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