m-Tolyl isocyanate → HCID 14880516, compound

HRID 1588845Notes

Reaction equation

HRID 1588845 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]([N:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5].[CH3:19][C:20]1[CH:21]=[C:22]([N:26]=[C:27]=[O:28])[CH:23]=[CH:24][CH:25]=1>>[CH3:19][C:20]1[CH:21]=[C:22]([NH:26][C:27](=[O:28])[NH:1][CH2:2][CH2:3][C:4]([N:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:5])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 14880496HCID 14880496, compound

Product 1

HCID 14880516HCID 14880516, compoundYield 55.1%

Procedure

Working in a manner similar to that described in Example 1, but starting with 3-amino-N,N-diphenylpropionamide (1 g) and 3-methylphenyl isocyanate (0.55 g), and after recrystallization in acetonitrile, 3-[3-(3-methylphenyl)ureido]-N,N-diphenylpropionamide (0.85 g), m.p. 179° C., is obtained.

Workup

  1. customafter recrystallization in acetonitrile

Sources & evidence

ORD record
ord-450ec21ee7f448d5a11271ab0bd522c1
Source dataset
uspto-grants-1993_06
Patent number
US05223529

Reaction notes

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