HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 4026994, compound → HCID 14880518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 4026994 | HCID 4026994 | — |
| Reactant | Tert-butyl 2-(phenylamino)acetate | HCID 12433731 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | HCID 14880518 | HCID 14880518 | 41.2% |
Reaction Steps
Working as in Example 15, but starting with (RS)-2-[3-(3-methylphenyl)ureido]-3-phenylpropanoic acid (4.8 g) and tert-butyl anilinoacetate (3.3 g) in anhydrous 1,2-dichloroethane (300 cc) and thionyl chloride (1.16 cc), and recrystallizing successively in diethyl ether and then in isopropanol, tert-butyl (RS)-N-{2-[3-(3-methylphenyl)ureido]-3-phenylpropionyl}-N-phenylglycinate (3.2 g), m.p. 198° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05223529 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-39d4dd4c81f14e9e8bec834cedaacf2c |
| Source note | uspto-grants-1993_06 |