m-Tolyl isocyanate → HCID 19754761, compound

HRID 1588854Notes

Reaction equation

HRID 1588854 reaction equation
[NH2:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])=[O:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH3:22][C:23]1[CH:24]=[C:25]([N:29]=[C:30]=[O:31])[CH:26]=[CH:27][CH:28]=1>>[CH3:22][C:23]1[CH:24]=[C:25]([NH:29][C:30](=[O:31])[NH:1][CH2:2][C:3]([N:5]([CH2:12][C:13]([N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])=[O:14])[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:4])[CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 19754758HCID 19754758, compound

Product 1

HCID 19754761HCID 19754761, compoundYield 44.8%

Procedure

Working in a manner similar to that described in Example 1, but starting with 2-(2-amino-N-phenylacetamido)-N,N-dipropylacetamide (1.7 g) and 3-methylphenyl isocyanate (0.77 g), and after recrystallization in acetonitrile, 2-{2-[3-(3-methylphenyl)ureido]-N-phenylacetamido}-N,N-dipropylacetamide (1.1 g), m.p. 182° C., is obtained.

Workup

  1. customafter recrystallization in acetonitrile

Sources & evidence

ORD record
ord-4e4cf938bb854f7e8b3af49e896dd1af
Source dataset
uspto-grants-1993_06
Patent number
US05223529

Reaction notes

Loading…