3,5-Dimethoxyphenol → HCID 19754903, compound

Participants

Reaction Steps

The reaction and workup were carried out in the same manner as described in Example 1 using p-bromobenzoic acid N-isopropyl-N-cyclohexyl amide (2.353 g, 7.26 mmol), 3,5-dimethoxy phenol (1.061 g, 6.88 mmol) and cuprous oxide (492 mg, 3.44 mmol) in 2,4,6-collidine (15 ml). The crude product was chromatographed on silica gel using mixtures of ethyl acetate and hexane as eluents to give the title compound as a crystalline solid that could be recrystallized from ethyl acetate and hexane, m. pt. 140.12° C. (DSC).

Provenance & Evidence